Cutaneous Manifestations of Lupus Erythematosus in Antananarivo (Madagascar)

Irina Mamisoa RANAIVO, Malalaniaina ANDRIANARISON, Fandresena Arilala SENDRASOA, Onivola RAHAROLAHY, Lala Soavina RAMAROZATOVO, Fahafahantsoa RAPELANORO RABENJA

Abstract


Introduction: Lupus erythematosus is a serious autoimmune inflammatory disease. Mucocutaneous manifestations are themain clinical manifestations, so our aim is to determine the different cutaneous manifestations of lupus erythematosus in Antananarivo.

Methods: A retrospective study was conducted over a period of 5 years from January 2007 to December 2011 in the medical derpartment of Joseph Raseta Befelatanana University Hospital.. All patients who presented lupus erythematosus were included.

Results: Among 57,509 patients seen in Joseph Raseta Befelatanana University Hospital, sixty seven cases of lupus erythematosus were included. The mean age was 35.08 years [minimum: 9; maximum: 69 years]. The sex ratio was 0.06. Among these 67 patients, forty six presented cutaneous manifestations (68, 65%). As specific lesions in lupus, chronic cutaneous lupus was observed in 47.82%, acute cutaneous lupus in 30.43% and subacute cutaneous lupus in 06.52% of patients. The other dermatological manifestations found were alopecia in 52.17%, photosensitivity in 43.47%, Raynaud's phenomenon in 17.39% and bullous lesions in 06.52% of patients.

Conclusion: A little difference was found in epidemiological, clinical and paraclinical aspects in lupus Malagasy patients and Africans. Lupus erythematosus is still a under-diagnosed disease in Madagascar. A deeper understanding of the cutaneous manifestations of SLE is essential for diagnosis and prognosis


Keywords


Lupus, cutaneous manifestations, Madagascar.

Full Text:

PDF

References


Dörner T, Furie R. Novel paradigms in systemic lupus erythematosus.Lancet. 2019 ; 393 : 2344-2358

Hajji1 M, Harzallah A, Kaaroud H, Ben Hamida F, Barbouch S, Kheder A. Les facteurs prédictifs de mortalité au cours du lupus. Néphrologie & Thérapeutique 2014 ; 10(5) : 275

Bouras M, Hali F, Khadir K, Benchikhi H. Lupus érythémateux systémique : mortalité et facteurs de mauvais pronostic dans une série marocaine de 129 cas. Ann Dermatol Vénéréol 2014 ; 141 : 141-143

Esmaeilzadeh E, Khodamoradi Z, Nazarinia MA. One-decade study of distinct features, morbidity and mortality of systemic lupus erythematosus (an update on systemic lupus erythematosus in the Fars Province of Iran). Lupus. 2019; 28(11):1360-1367.

Gergianaki I, Fanouriakis A, Repa A, et al. Epidemiology and burden of systemic lupus erythematosus in a Southern European population: Data from the community-based lupus registry of Crete, Greece. Ann Rheum Dis 2017; 76: 1992–200

Kombate K, Saka B, Oniankitan OI et al. Le Lupus Systé-mique à Lomé, Togo Med Trop 2008; 68: 283-286

Teclessou N J, Kombaté K, Akakpo A S, Saka B, Mouhari-Toure A, Matakloé H, Pitche P. Maladie lupique en milieu hospitalier à Lomé : Etude rétrospective de 116 cas. RAFMI 2017 ; 4 (1-1): 19-23

Diop M M, Gueye Y A, Lèye A, Touré P S, Berthe A, KA M M. Les modes de révélation du lupus érythémateux systémique à Dakar (Sénégal) : à propos d’une série de 161 cas. RAFMI. 2014 ; 1(2): 1-15

Louzir B, Othmani S, Ben Abdelhafidh N. Le lupus érythémateux systémique en Tunisie. Étude multicentrique nationale. À propos de 295 observations. Rev Méd Int 2003 ; 24 :768–77

Bouatba L, Bachir H, Ammouri W,et al. Lupus érythémateux systémique au Maroc: étude analytique monocentrique de 440 patients. Rev Méd Int 2014 ; 35S : A142

Deligny C, Thomas L, Dubreuil F et al. Lupus systémique en Martinique: enquête épidémiologique. Rev Med Int. 2002; 23(1): 21-29

Al-Maini MH, El-Ageb EM, Al-Wahaibi SS, Al-Farsi Y, Richens ER. Demographic, autoimmune, and clinical profiles of patients with systemic lupus erythematosus in Oman. Rheumatol Int. 2003; 23(4):186-191

Fandresena FA, Ranaivo IM, Razanakoto NH et al. Limited Management of Systemic Erythematosus Lupus in Madagascar. International Journal of Clinical Dermatology. 2017; 1(1): 1-4. doi: 10.11648/j. ijcd.20170101.11

Ranaivo IM, Sendrasoa FA, Harioly Nirina MOJ, Self-Medication during Dermatological Disorders Seen in the Dermatology Department of the University Hospital Joseph Raseta Befelatanana, Antananarivo Madagascar. EC Microbiology 2019 ; 15 (5) : 339-343

Doffoel-Hantz V, Savi V. Principales manifestations dermatologiques du lupus érythémateux disséminé. Actualités pharmaceutiques 2017 ; 567 : 22- 25

Larbi T, Abdelkefi C, Elouni A, Bouslema K, Hamzaoui S, M’rad S. Manifestations dermatologiques du lupus érythémateux systémique. Rev Méd Int 2015 ; 36S : A96

Francès C, Barète S, Piette J-C. Manifestations dermatologiques du lupus. Rev Méd Int 2008 ; 29 : 701–709

G. Bens. Photosensibilité du lupus érythémateux. Rev Méd Int 2009 ; 30 : 857–865

Ahluwalia J, Marsch A. Photosensitivity and photoprotection in patients with lupus erythematosus Lupus 2019; 0: 1–6.

Jira M, Elqatni M, Sekkach Y, Elomri N, Mekouar F, Ghafir D. Étude de trois cas de lupus érythémateux bulleux. Ann Dermatol Vénéréol 2013 ; 140, 778—783]


Refbacks

  • There are currently no refbacks.


Copyright (c) 2019 Irina Mamisoa RANAIVO

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.