Human" C-Reactive Protein (CRP) 1919 A/T" Polymorphism in Patients with Breast Cancer

Zafir Hassan Ghali

Abstract


"C-reactive protein (CRP)" demonstrates essential prognosis in many diseases due to its vital role in inflammation response Breast cancer is the most common cancer in the world and is the second largest among the various types of cancer among women...In this study we aimed to determine the frequency of "SNP   rs1417938 of CRP gene "and investigate this polymorphism in a group breast cancer patients. The most common "CRP 1919 (rs1417938)" was evaluated in 20 patients with breast cancer A allele is a major one in the studied population. This allele is more common in breast cancer patients (1.00). The patients with breast cancer are more likely to own AA genotypes. The individuals with genotype AT or TT have not been detected in the studied groups. These preliminary data can be considered as pilot ones. These data give reason to assume that A is a predisposing allele to breast cancer. 


Keywords


C-reactive protein, polymorphism,breast cancer,genotype

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