Crohn’s Disease in South Asia

Umesh Jayarajah, N M Navarathne, Ishan M de Zoysa, Nishanthan Subramaniam, Nandadeva Samarasekera, Suranjith L Seneviratne

Abstract


Crohn’s disease (CD) is a highly complex disease of unknown aetiology. We analysed the epidemiology, clinical characteristics, diagnosis, treatment and pathogenesis of Crohn’s disease in South Asia compared to the rest of the world.The PubMed database and Google scholar were searched till March 2016 for articles on CD. Articles dealing with CD in South Asians were reviewed by the authors, critically analyzed and then summarized.

There is a lower incidence of CD in South Asia compared to the West and disease characteristics differ. Although novel genetic factors associated with CD have been identified, significant gaps exist in relation to disease pathogenesis, molecular genetic mechanisms and the use of evidence based treatment modalities.

Our review provides a comprehensive overview of existing knowledge on CD in South Asia and identifies gaps in knowledge for future research 

 


Keywords


Crohn’s disease, South Asia, Epidemiology, genetics, clinical features, treatment

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References


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Copyright (c) 2017 Umesh Jayarajah, N M Navarathne, Ishan M de Zoysa, Nishanthan Subramaniam, Nandadeva Samarasekera, Suranjith L Seneviratne

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