The expression level of Mir-210 and Mir-141 in breast cancer patients

Shima Hojabri Mahani, Saeedeh Hosseini abnavi, Roya Zarezadeh, Mojtaba Mohammadnejad Pahmadani, Zoofa Zayani, Maryam Nooshin

Abstract


Background: Breast cancer is a clinically heterogeneous disease. Molecular classification of breast cancer has been proposed based on gene expression profiles of human tumors. Luminal, basal-like, normal-like, and erbB2+ subgroups were identified and were shown to have different prognoses. Breast cancer is the most common cancer among women worldwide, with 1.3 million women diagnosed each year and about 500,000 deaths per year from the disease. Recently molecular studies have been conducted on early diagnosis of breast cancer. In this study, expression levels of Mir-210 and Mir-141 were reported in breast cancer samples.    Methods: The expression levels of Mir-210 and Mir-141 were checked by Real Time-PCR method in 35 breast cancer tissues and 35 adjacent normal tissues.  Results: This study for Mir-210 reported that 42.8% of tumor samples have increased of expression levels comparison with normal samples and 45.8% of tumor samples showed an increase in expression level for Mir-141. Finally, was not observed significant difference between the levels of expression in these microRNAs (P>0.05).


Keywords


Breast Cancer, Mir-210, Mir-141, Real Time-PCR Method.

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References


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