Effects of Pausinystalia Yohimbe Methanol Root Extract on Some Cardiovascular and Hematological Variables in Wistar Rats

Adekunle Orimisan Ojatula


Plants have been a major source of medicine and have been largely considered to alter the range of blood pressure and parameters. The present study was undertaken to investigate the effect of Pausinystalia yohimbeon blood pressure and haematological factors in normotensive male wistar rats. The rats were randomly divided into four groups of nine rats each. The control group received 1 mL/kg distilled water while the three treatment groups received 25 mg/kg, 50 mg/kg and 100 mg/kg of the extract respectively, and the blood pressure was measured three hours thereafter. After the study period, blood samples were taken from experimental rats, and haematological factors were determined using digital cell counter. Administration of the extract, caused a dose-dependent fall in blood pressure and heart rate, and appeared to increase leucocyte (WBC and lymphocytes) and erythrocyte parameters (RBC, HCT and Hgb) when compared with the control group. While thrombocyte parameters (PLT and Pct) were decreased. The findings demonstrated that acute hypotensive and antitarchycardiac effect of the extract may be due to direct effect of the metabolites on cardiac-vascular smooth muscle, and that Pausinystalia yohimbe does not cause any significant undesirable alterations in haematological factors in wistar rats. It also enhances white blood cell concentration and lymphocytes which probably stimulate the immune defence mechanism.


Medicinal Plants, Hypertension, Immune System, Pausinystalia Yohimbe,Wistar Rats.

Full Text:



A .O.Ojatula, “Bioactivity and safety assessment of Pausinystaliayohimbe (K. Schum.) Pierre ex Beille root extract on male sexual and spermatic parameters in wistarrats,”UnpublishedPh.D. Dessertation,phytomedicine, University of Benin, Benin City, Nigeria. 266p, 2017.

J. A. Akinninyi, M. U. A. Sultanbawa, and D. Manawadu, “Ethnobotany and ethnopharmacology of the Nigerian medicinal plants. In: Sofowora, A. (Ed.) The State of Medicinal Plant Research in Nigeria,” University Press, Ibadan. pp. 157-164, 1986.

P. Mupago, and I. A. Raji, “Effects of aqueous leaf extract of Asystasiagangeticaon the blood pressure and heart rate in male spontaneously hypertensive wistar rats,” Hypertension, vol. 01, pp. 283-289, 2013.

J. T. Talha, M. T. Priyanka, and A. Akanksha,“Hypertension and herbal plants,”International Research Journal of Pharmacy, vol. 81, pp. 350-357, 2011.

J. Vergara-Galica, R. Ortiz-Andrade, and J. Rivera-Leyva,“Vasorelaxant and antihypertensive effects of metabolic extract from roots of Laeliaanceps are mediated by calcium channel antagonism,”Fitoterapia, vol. 81, pp. 350-357, 2010.

P. M. Kearney, M. Whelton, and K. Reynolds, “Global burden of hypertension: analysis of worldwide data,”Lancet, vol. 365, pp. 217-223, 2005.

WHO. The global importance of plant derived drugs. [Available at: www.who.org] [Assessed: September 2, 2012].

M. Idu, E. K. I. Omogbai, F. Amaechina, and J. E. Ataman, “Some cardiovascular effects of the aqueous extract of the leaves of Stachtarphetajamaicensis,”International Journal of Pharmacy, vol. 2, no. 2, pp. 163-165, 2006.

F. I.Abdulrahman, J. C. Akan, O. A. Sodipo, and P. A. Onyeyilli,“Effect of aqueous root bark extract of Vitexdomina sweet on haematologicalparamenters in rats,”Journal of American Science, vol. 6, pp. 8-12, 2010.

Anonymous. Pausinystaliayohimbe. [Available at: https://en. wikipedia. org/wiki/

Pausinytaliayohimbe] [Assessed: September 23, 2015].

M. Sala, D. Braida, and E. Gori, “Central effect of yohimbine on sexual behaviour in rat,”Physiology and Behaviour, vol. 47, pp. 165-173, 1990.

J. V. Dacie, and S. M. Lewis, “Practical Haematology, 6th Edition,”Churchill Livingston, Edinburgh, p. 236, 1984.

O. N. Anaka, R. I. Ozula, andS. O. Okpo, “Effect of the aqueous seed extract of Perseaamericana on the blood pressure of sprague-dawley rats,”African Journal of Pharmacy andPhamarcology, vol. 3, no. 1, pp.485-490, 2009.

B. A. Ayinde, E. K. I. Omogbai, and D. N. Onwukaeme, “Pharmacognostic characteristics and hypotensive effect of the stem bark of Musangacecropioides,”West African Journal of Pharmacology and Drug Research, vol. 19, pp. 37-41, 2003.

K. T. Kashinath,“Hypolipidemic effect of disulphide in rats fed high lipids diet and/or ethanol. Ph.D Thesis,” University of Bangalore, p. 210, 1990.

K. D. Effraim, H. A. Salami, and T. U. Jacks,“Effect of aqueous extract of Corynantheyohimbe bark on some Haematological parameters in albino rats,” Pakistan Vetrinary Journal, vol. 17, no. 4, pp. 203-204, 1997.

H. C. Kwaan, “Changes in blood coagulation, platelet function and plasminogen-plasmin system in diabetes,” Diabetes, vol. 41, pp. 32-35, 1992.


  • There are currently no refbacks.

Copyright (c) 2020 Adekunle Orimisan Ojatula

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.