A3872G polymorphism of " C-reactive protein gene (CRP)" in patients with breast cancer

Intisar Hussein Ahmed


"C-reactive protein (CRP)" is the phenotype intense stage protein initiated by hepatocytes, known as an inflammatory biomarker." CRP "is related with an extensive variety of infections, including atherosclerosis and diabetes mellitus. Breast malignancy remains a noteworthy issue of women' wellbeing and its rate is expanding worldwide .Due to importance of CRP polymorphism, we aimed to determine the frequency of "SNP   rs1205 of CRP gene" and investigate this polymorphism in a group 20 breast cancer patients. G allele is a major one in the studied population. This allele is more common in breast cancer patents (1.00). The minor allele in patients with breast cancer is T .The patients with breast cancer are more likely to own GG genotypes.  These preliminary data can be considered as pilot ones. These data give reason to assume that G is a predisposing allele to breast cancer.


C-reactive protein, polymorphism,breast cancer,genotype

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Danesh J. and Pepys M.B. C-reactive protein in healthy and in sick populations. Eur. Heart J. 2000 ; 21, 1564–1565.

Danesh J., Wheeler J.G., Hirschfield G.M., Eda S., Eiriksdottir G., Rumley A. et al. C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease. N. Engl. J. Med. 2004; 350, 1387–1397.

Ferlay J. et al. GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11 [Internet]. Lyon, Fr. Int. Agency Res. Cancer. 2013. Available from: http://globocan.iarc.fr, accessed on 11/20/2014.

Maccio A., Madeddu C. & Mantovani G. Adipose tissue as target organ in the treatment of hormone-dependent breast cancer: new therapeutic perspectives. Obes. Rev. 2009; 10, 660–670 .

Heikkilä K. et al. Associations of circulating C-reactive protein and interleukin-6 with cancer risk: findings from two prospective cohorts and a meta-analysis. Cancer Causes Control2009; 20, 15–26 .

Poole E. M. et al. A prospective study of circulating C-reactive protein, interleukin-6, and tumor necrosis factor α receptor 2 levels and risk of ovarian cancer. Am. J. Epidemiol , kwt2013; 098 .

Nimptsch K., Aleksandrova K., Boeing H., Janke J., Lee Y.A., Jenab M. et al. Association of CRP genetic variants with blood concentrations of C-reactive protein and colorectal cancer risk. Int. J. Cancer 2015;136, 1181–1192 .

Ognjanovic S., Yamamoto J., Saltzman B., Franke A., Ognjanovic M., Yokochi L. et al. Serum CRP and IL-6, genetic variants and risk of colorectal adenoma in a multiethnic population. Cancer Causes Control 2010;21, 1131–1138.

Siemes C., Visser L.E., Coebergh J.W., Splinter T.A., Witteman J.C., Uitterlinden A.G. et al. C-reactive protein levels, variation in the C-reactive protein gene, and cancer risk: the Rotterdam Study. J. Clin. Oncol. 2006; 24, 5216–5222.

Slattery M.L., Curtin K., Poole E.M., Duggan D.J., Samowitz W.S., Peters U. et al. Genetic variation in C-reactive protein in relation to colon and rectal cancer risk and survival. Int. J. Cancer 2011; 128, 2726–2734.

Tsilidis K.K., Helzlsouer K.J., Smith M.W., Grinberg V., Hoffman-Bolton J., Clipp S.L. et al. Association of common polymorphisms in IL10, and in other genes related to inflammatory response and obesity with colorectal cancer. Cancer Causes Control 2009; 20, 1739–1751 .

Pankow JS, Folsom AR, Cushman M, Borecki IB, Hopkins PN, Eckfeldt JH, Tracy RP: Familial and genetic determinants of systemic markers of inflammation: the NHLBI family heart study. Atherosclerosis 2001;154:681-9.

Slattery ML, Curtin K, Poole EM, Duggan DJ, Samowitz WS, Peters U, Caan J, Potter JD, Ulrich CM : Genetic variation in C-reactive protein (CRP) in relation to colon and rectal cancer risk and survival. Int J Cancer 2011;128: 2726-2733,.

Minamiya, Y., Miura, M., Hinai, Y., Saito, H., Ito, M., Imai, K., Ono, T., Motoyama, S. & Ogawa, J. The CRP 1846T/T genotype is associated with a poor prognosis in patients with non-small cell lung cancer. Tumor Biol2010;. 31, 673-679.

Polterauer, S., Grimm, C., Zeillinger, R., Heinze, G., Tempfer, C., Reinthaller, A. & Hefler, L. Association of C-reactive protein (CRP) gene polymorphisms, serum CRP levels and cervical cancer prognosis. Anticancer Res. 2011; 31, 2259-2264.


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