Antihyperglycemic Effect Of Ethanol Extract Of Fruiting Bodies Of Organically Cultivated Pleurotus Ostreatus In High Sucrose High Fat Diet Streptozotocin Induced Diabetes In Rats

Samuel C. Onuoha, Prince N. Okoroh, Augustine A. Uwakwe, Comfort C. Monago-Ighoroje, Young C. Ukegbu, Chidinma O. Chukwuka


The effect of ethanol extract  of the fruiting bodies of Pleurotus ostreatus (POE)and metformin Hydrochloride on the body weight and blood glucose profile of high sucrose high fat diet streptozotocin induced diabetic rats was investigated.   The experimental model was 20% High Sucrose (HS) + 20% High Fat Diet (HFD) + 35mg/kg body weight (via intraperitoneal) streptozotocin (STZ) induced diabetic rat model, with the fruiting body ethanol extracts administered orally at 50, 150 and 300mg/kg  .The Metformin HCl and ethanol extract was given once daily by intragastric gavage to the reference and experimental groups respectively at doses 150mg/Kg b.w., 50mg/Kg   b.w, 150mg/Kg b.w. and 300mg/Kg b.w. respectively while the normal control received saline solution for 88days . POE caused significantly dose – (p<0.05) and time dependent reduction (p<0.05) in blood glucose levels of HS-HFD-STZ- induced diabetic rats. The blood glucose concentration of diabetic rats indicated a tendency to normal levels after administration of POE at 300mg/kg and 50mg/kg respectively but metformin HCl, (150mg/kg b.w,) showed a greater blood glucose level reduction effect in 9weeks of treatment. Ethanol extract of Pleorotus ostreatus significantly (p<0.05), dose and time dependently restored body weights and blood glucose of rats. Results highlighted  show that ethanol extracts of organically cultivated  mushroom  has anti-diabetic properties, suggesting that people may use it in medicinal formulation processes for the management of diabetes mellitus and its associated complications.


Body weight, Diabetes mellitus, Pleurotus ostreatus, blood glucose, anti-hyperglycemic effect

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