KMT2D and IGF2 Genes Expression in Breast Cancer Patients

Alireza Tavakolpour Negari, Alireza Emamvirdizadeh, Mahta Majdnia, Arash Matin Ahmadi, Fatemeh Shahbazi, Ameneh Molaei, Seyed Hesamoddin Bidooki


Background: Breast cancer which is often a cancer in women, is one of the most important public health problems and 1,384,155 new cases worldwide are associated with 459,000 deaths. Breast cancer is highly heterogeneous in its pathological characteristics. Current predictions and statistics suggest that both worldwide incidence of breast cancer and related mortality are on the rise. So far, many studies have been conducted on various genes in breast cancer that can help to treat this cancer. Methods: The gene expression of KMT2D and IGF2 were investigated in 35 samples with breast cancer after genomic RNA extraction and synthesis cDNA using quantitative real-time PCR method. Result: There was no significant difference in the expression of KMT2D and IGF2 genes in breast tumor samples compared to adjacent normal samples (P > 0.05). However, this study was designed as a pilot study, and further investigations are required to confirm our findings.


Gene Expression; KMT2D; IGF2; Quantitative Real-Time PCR Method; Breast Cancer.

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