Assessing Expression of TGF- Β2 and PCDH9 Genes in Breast Cancer Patients

Seyed Hesamoddin Bidoki, Arash Bayatani, Mahsa Sarlak, Milad Rasouli, Paria Mostafaie, Mona Saghafi, Alireza Tavakolpour Negari

Abstract


Background: Breast cancer is the most commonly occurring cancer in women, comprising almost one third of all malignancies in females. The evolution of breast cancer is a multistep process involving genetic, epigenetic, and environmental factor interactions that result in the dysregulation of key oncogenes and tumor suppressor genes, culminating in activation of cancer-related signaling pathways. It has been broadly recognized that cancer is a disease caused by molecular alterations in either proto-oncogenes or tumor suppressor genes. In order to make an impact on breast cancer, we must understand the molecular abnormalities to target better therapeutics.

Methods: The expression status of PCDH9 and TGF-β2 genes were checked in 35 patients with breast cancer tissues and 35 adjacent normal tissues using the q-PCR method.

Result: This paper reported that there was no significant difference between expression level of tumor samples and adjacent normal samples (P > 0.05). However, this study was designed as a pilot study, and further investigations are required to confirm our findings.


Keywords


Quantitative Real-Time PCR Method; Breast Cancer; PCDH9; TGF-Β2.

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