Nanotechnology in Sepsis: Diagnosis and Treatment, Review

Maged Naser, Mohamed M. Naser, Lamia H. Shehata



Sepsis is one of the main reasons of deaths internationally, with excessive mortality rates and a pathological complexity hindering early and correct diagnosis. Today, laboratory culture checks are the epitome of pathogen recognition in sepsis. However, their consistency stays a problem of controversy with false negative results frequently observed. Clinically used blood markers, C reactive protein (CRP) and procalcitonin (PCT) are indications of an acute-phase response and as a result lack specificity, supplying restrained diagnostic efficacy. In addition to bad diagnosis, inefficient drug delivery and the increasing prevalence of antibiotic-resistant microorganisms represent significant obstacles in antibiotic stewardship and hinder high quality therapy. These challenges have brought on the exploration for choice techniques that pursue accurate prognosis and high-quality treatment. Nanomaterials are examined for each diagnostic and therapeutic functions in sepsis. The nanoparticle (NP)-enabled seize of sepsis causative agents and/or sepsis biomarkers in biofluids can revolutionize sepsis diagnosis.

 From the therapeutic factor of view, presently current nanoscale drug transport structures have established to be extraordinary allies in focused therapy, whilst many different nanotherapeutic functions are envisioned. Herein, the most applicable purposes of nanomedicine for the diagnosis, prognosis, and treatment of sepsis is reviewed, imparting a quintessential evaluation of their potentiality for scientific translation.


Nanotechnology, sepsis, diagnosis, progression, therapy.

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