The Preventive Effect of Curcumin Analogs (AKS-k) From Cullilawan Oil as Hepatoprotector in Rats (Rattus norvegicus L.) Induced By CCl4

Imanuel berly delvis kapelle, Wasmen Manalu

Abstract


Curcumin analogue from cullilawan oil using safrole as a precursor have the potential to cure liver function. The synthesis process method has an effect on its pharmacological effect. The effectiveness of this synthetic product as a deterrent to liver disease needs to be studied, so the aim of this study was to determine the preventive effect of curcumin analog from cullilawan oil as hepatoprotectors in rats (Rattus norvegicus L.) induced by CCl4. The method used is in vivo method using rats (Rattus norvegicus L.) and as a comparison material using turmeric extract (curcumin) and heap-q products. The results showed that AKS-k products had a preventive effect on liver function in male rats (Rattus norvegicus L.) induced by CCl4 with an effective dosition of 52 mg / 200g bb.


Keywords


Hepatoprotector, AKS-k, Preventive, Rattus norvegicus L.

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References


. Kapelle IBD, Irawadi TT, Rusli MS, Mangunwidjaja D, Mas’ud ZA. 2015. Synthesis of New Curcumin Analogues from Kulit Lawang Oils Using the Conventional Method and Microwave. Science Journal of Chemistry. 3(3): 50-56.

. Kapelle IBD, Irawadi TT, Rusli MS, Mangunwidjaja D, Mas’ud ZA. 2016. Rekayasa proses sintesis piperonal kulit lawang (Cinnamomum culilawan blume) sebagai prekursor obet kanker. Jurnal Penelitian Hasil Hutan. Kementrian Lungkungan hidup dan kehutanan, Puslitbang. 34(3) : 217-229.

. Kapelle IBD, Irawadi TT, Rusli MS, Mangunwidjaja D, Mas’ud ZA. 2015. The Influence of Synthesis Methods Against Anti-Cancer Activity of Curcumin Analogous. Cancer Research Journal. 3(4): 68-75.

. Yang CH, Yue J, Sims M, Pfeffer LM. 2013. The curcumin analog EF24 targets NF-kB and miRNA-21, and has potent anticancer activity in vitro and in vivo. PLoS ONE. 8(8): e71130.

. Johnson JJ, Mukhtar H. 2007. Curcumin for chemoprevention of colon cancer. Cancer Letters. 255:170–181.

. Khan RA, Khan MR, Ahmed M, Sahreen S, Shah NA, Shah MS, Bokhari J, Rashid U, Ahmad B, Jan S. 2012. Hepatoprotection with a chloroform extract of Launaea procumbens against CCl4-induced injuries in rats. BMC Complementary and Alternative Medicine. 12:114.

. Burt AD, Portmann BC, Ferrel LB. 2007. Pathology of the liver (Fifth edition). NY : Churchill Livingstone

. Weber L, Boll M, Stampfl A. 2003. Hepatotoxicity and Mechanism of Action of Haloalkanes: Carbon Tetrachloride as a Toxicological Model. Critical Reviews in Toxicology. 33:105-136.

. Ruhu P, McDonald R. 2001. Use of antioxidant nutrient in the prevention and treatment of type 2 Diabetes. Journal of the American college of nutrition. 20(5), 363-369.


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